The rape of little Enis August 15, 2007 by Francis Evrard, already convicted three times has reignited the debate on monitoring pedophiles to their release. Updates on drug treatments, including hormone.
What is the chemical treatment?
The doctor prescribed substances designed to reduce sexual desire. These drugs are 3 types:
- Certain antidepressants (called Selective inhibitors of serotonin reuptake or SSRIs);
- Antiandrogen drugs, so called because they oppose the action of androgens or male sex hormones;
- Some drugs that decrease the secretion of testosterone, the principal male sex hormone, these drugs are called GnRH agonists.
The SSRI antidepressants have limited efficacy, while antiandrogens and GnRH agonists are considered more effective.
Androcur (cyproterone acetate) is a derivative of progesterone. In humans, it blocks the action of testosterone in preventing one of its byproducts, dihydrotestosterone from binding to its cellular receptors.
The ENANTON (leuprolide) is a drug that mimics the action of a hormone (GnRH or LHRH), released by the hypothalamus in the brain. GnRH sends messages to the pituitary gland in the brain, which orders the testes to produce testosterone. GnRH is not produced continuously, but by pulsations. If there was continued production of GnRH by the hypothalamus would have the opposite effect and "turn off" hormone production. Precisely what the leuprolide. In men, leuprolide reduces therefore the amount of testosterone produced by the testes.
How do I use are these drugs?
Androcur is in the form of tablets containing 50 milligrams of active drug. The most common protocol is to give Androcur 2 milligrams per kilogram of body weight per day, for a patient of 75 kg, 3 tablets (150 mg) per day. Treatment effects disappear one to two months after discontinuation.
The ENANTON is administered monthly by subcutaneous injection of 3.75 milligrams of active ingredient. The effect of this drug lasts 4 weeks. During the first month of treatment ENANTON, it is necessary to give Androcur in parallel. Indeed, during the first month, the ENANTON increases the secretion of testosterone before the fall.
For both drugs, treatment can be effective only if followed over a long period. This period is usually 24 months.
These drugs are effective?
Little is known about their actual effectiveness. Androcur treatment seems to reduce to less than 10% recidivism rate, compared with over 80% off treatment. Cons placebo studies are underway in several countries to determine the most appropriate treatment.
What is the chemical treatment?
The doctor prescribed substances designed to reduce sexual desire. These drugs are 3 types:
- Certain antidepressants (called Selective inhibitors of serotonin reuptake or SSRIs);
- Antiandrogen drugs, so called because they oppose the action of androgens or male sex hormones;
- Some drugs that decrease the secretion of testosterone, the principal male sex hormone, these drugs are called GnRH agonists.
The SSRI antidepressants have limited efficacy, while antiandrogens and GnRH agonists are considered more effective.
Androcur (cyproterone acetate) is a derivative of progesterone. In humans, it blocks the action of testosterone in preventing one of its byproducts, dihydrotestosterone from binding to its cellular receptors.
The ENANTON (leuprolide) is a drug that mimics the action of a hormone (GnRH or LHRH), released by the hypothalamus in the brain. GnRH sends messages to the pituitary gland in the brain, which orders the testes to produce testosterone. GnRH is not produced continuously, but by pulsations. If there was continued production of GnRH by the hypothalamus would have the opposite effect and "turn off" hormone production. Precisely what the leuprolide. In men, leuprolide reduces therefore the amount of testosterone produced by the testes.
How do I use are these drugs?
Androcur is in the form of tablets containing 50 milligrams of active drug. The most common protocol is to give Androcur 2 milligrams per kilogram of body weight per day, for a patient of 75 kg, 3 tablets (150 mg) per day. Treatment effects disappear one to two months after discontinuation.
The ENANTON is administered monthly by subcutaneous injection of 3.75 milligrams of active ingredient. The effect of this drug lasts 4 weeks. During the first month of treatment ENANTON, it is necessary to give Androcur in parallel. Indeed, during the first month, the ENANTON increases the secretion of testosterone before the fall.
For both drugs, treatment can be effective only if followed over a long period. This period is usually 24 months.
These drugs are effective?
Little is known about their actual effectiveness. Androcur treatment seems to reduce to less than 10% recidivism rate, compared with over 80% off treatment. Cons placebo studies are underway in several countries to determine the most appropriate treatment.
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